| Pair Name | Polyphyllin VI, Doxorubicin | ||
| Phytochemical Name | Polyphyllin VI (PubChem CID: 10417550 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Polyphyllin VI, Doxorubicin | |||
| Disease Info | [ICD-11: 2B91.Z] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Up-regulation | Expression | MAP1LC3A | hsa84557 |
| Up-regulation | Expression | BECN1 | hsa8678 | |
| Down-regulation | Expression | AKT1 | hsa207 | |
| In Vitro Model | DLD-1 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0248 |
| Result | Our results suggest that EEPP deserves further evaluation for development as complementary chemotherapy for colorectal cancer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Paris Polyphylla Inhibits Colorectal Cancer Cells via Inducing Autophagy and Enhancing the Efficacy of Chemotherapeutic Drug Doxorubicin. Molecules. 2019 Jun 3;24(11):2102. doi: 10.3390/molecules24112102. | Click |
